+- +-

+-User

Welcome, Guest.
Please login or register.
 
 
 
Forgot your password?

+-Stats ezBlock

Members
Total Members: 78
Latest: Solkthove
New This Month: 0
New This Week: 0
New Today: 0
Stats
Total Posts: 104
Total Topics: 75
Most Online Today: 1
Most Online Ever: 22
(May 28, 2019, 04:37:54 am)
Users Online
Members: 0
Guests: 1
Total: 1

Author Topic: Collagen/chitosan porous scaffolds for skin tissue engineering  (Read 537 times)

0 Members and 0 Guests are viewing this topic.

fmsbi

  • Global Moderator
  • Newbie
  • *****
  • Posts: 20
Collagen/chitosan porous scaffolds for skin tissue engineering
« on: December 26, 2014, 04:16:46 am »
Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering

Lie Maa, Changyou Gaoa, , , Zhengwei Maoa, Jie Zhoua, Jiacong Shena, Xueqing Hub, Chunmao Hanb

Porous scaffolds for skin tissue engineering were fabricated by freeze-drying the mixture of collagen and chitosan solutions. Glutaraldehyde (GA) was used to treat the scaffolds to improve their biostability. Confocal laser scanning microscopy observation confirmed the even distribution of these two constituent materials in the scaffold. The GA concentrations have a slight effect on the cross-section morphology and the swelling ratios of the cross-linked scaffolds. The collagenase digestion test proved that the presence of chitosan can obviously improve the biostability of the collagen/chitosan scaffold under the GA treatment, where chitosan might function as a cross-linking bridge. A detail investigation found that a steady increase of the biostability of the collagen/chitosan scaffold was achieved when GA concentration was lower than 0.1%, then was less influenced at a still higher GA concentration up to 0.25%. In vitro culture of human dermal fibroblasts proved that the GA-treated scaffold could retain the original good cytocompatibility of collagen to effectively accelerate cell infiltration and proliferation. In vivo animal tests further revealed that the scaffold could sufficiently support and accelerate the fibroblasts infiltration from the surrounding tissue. Immunohistochemistry analysis of the scaffold embedded for 28 days indicated that the biodegradation of the 0.25% GA-treated scaffold is a long-term process. All these results suggest that collagen/chitosan scaffold cross-linked by GA is a potential candidate for dermal equivalent with enhanced biostability and good biocompatibility.

http://www.sciencedirect.com/science/article/pii/S0142961203003740
« Last Edit: December 26, 2014, 06:14:38 pm by fmsbi »

Share on Facebook Share on Twitter


SSamani

  • Board Moderator
  • Newbie
  • *
  • Posts: 39
Hi
Hyperlink was broken. ???
Download full article.
Thanks
« Last Edit: April 22, 2015, 12:19:22 am by SSamani »
The true sign of intelligence is not knowledge but imagination. Albert Einstein

fmsbi

  • Global Moderator
  • Newbie
  • *****
  • Posts: 20
ممنون از توصیه شما
خوشبختانه موفق به اصلاح لینک شدم
با تشکر

 

Recent Posts ezBlock

Re: سایت انجمن by nourani
February 21, 2017, 10:10:10 am

سایت انجمن by nourani
February 21, 2017, 10:08:58 am

دومین کنگره سراسری پیشرفت‌های مهندسی باف by nourani
November 06, 2015, 10:53:12 pm

2015 TERMIS World Congress by nourani
September 03, 2015, 05:03:47 am

Dr. Zohreh Bagher The first PhD in Tissue Engineering graduated from IUMS by nourani
July 01, 2015, 04:27:43 pm

Journal of Applied Tissue Engineering was published by nourani
June 14, 2015, 09:30:06 pm

Antibacterial Hydroxyapatite (A review) by SSamani
May 02, 2015, 02:36:54 pm

Bone grafting is a big business by nourani
April 22, 2015, 09:38:11 pm

Controlled Dual Release of Functional Molecules by SSamani
April 20, 2015, 11:53:23 pm

Hyaluronic Acid Hydrogel: A Favourable Niche for Neural Stem Cells by SSamani
March 28, 2015, 01:59:53 am