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Author Topic: Development of a Nerve Growth Conduit for Peripheral Nerve Regeneration  (Read 1248 times)

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Development of a Nerve Growth Conduit for Peripheral Nerve Regeneration

Mohammad Reza Nourani1*

1Tissue Engineering Research Center, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

*Corresponding author: Mohammad Reza Nourani, PhD, Tissue Engineering Research Center, Applied Biotechnology Research Center, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave, Tehran, Iran. Tel: +98 21 8821 1523; Fax: +98 21 8821 1524; E-mail: r.nourani@yahoo.com

In peripheral nerve injuries, the gap between the proximal and distal ends of the injured nerve should be bridged by a tube-shape implant in order to guide the sprouts sent out by the proximal end to the distal end. Application of both autografts and allografts are limited; the former by availability of donor tissue, donor site morbidity and formation of neuroma; and the latter by its low potential in promotion of nerve regeneration and the risk of transmission of pathogens. Therefore, conduits made of different biomaterials have been developed to regenerate a nerve gap wider than 10 mm. In this study, different biomaterial solutions were prepared. Then, a mandrel was soaked in the solutions and freeze-dried. The conduits underwent SEM for assessment of pores size and surface morphology and FTIR for evaluation of chemical structure. Also, MTT assay was performed using rat mesenchymal stem cell lines to test for cytotoxicity. A final histopathological study was performed too. The results showed that the conduits had a highly porous fine structure with interconnected and partly equal-sized pores. FTIR spectra showed presence of ordinary functional groups. In vitro studies confirmed the ability of the conduits to support growth of fibroblast cells and histopathological study revealed the growing processes of nerve fibers from the proximal end of the cut nerve to its distal end. It could be concluded that the nerve growth conduit is suitable for guiding axonal growth and supporting peripheral nerve regeneration. In this presentation, different types of nerve conduits are explained.

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« Last Edit: April 22, 2015, 12:23:16 am by SSamani »
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