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Author Topic: Hyaluronic Acid Hydrogel: A Favourable Niche for Neural Stem Cells  (Read 140323 times)

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Injury in the central nervous system (CNS) is very serious and may result in permanent disability of the patients, since it causes neural cell death and tissue defects. There have been no effective therapies so far, unfortunately. Many studies have already shown that neural stem cells (NSC) can be used for treatment of certain neurological diseases because they have the intrinsic ability of self-renewal. However, the effect of NSC grafting for neural restoration has been proven to be rather limited because of low viability and undesired differentiation in vivo.
It is critical therefore, that creation of a suitable microenvironment or niche, composed of cells, blood vessels, growth factors and the extracellular matrix (ECM), would play an important role in regulating neurogenesis, survival and regeneration of NSC. Thus, certain biomaterials used for neural tissue engineering may offer a promising approach for creating
such a microenvironment, since they provide biological scaffolds which can sustain the stem cells for transplantation and neural regrowth in vivo.
Among those materials, the hyaluronic acid (HA)-based biodegradable hydrogel has been proven to mimic brain ECM effectively and to provide a good scaffold that is easily modified with different useful molecules for promoting regeneration
in the injured CNS.
« Last Edit: April 22, 2015, 12:28:04 am by SSamani »
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