+- +-

+-User

Welcome, Guest.
Please login or register.
 
 
 
Forgot your password?

+-Stats ezBlock

Members
Total Members: 78
Latest: Solkthove
New This Month: 0
New This Week: 0
New Today: 0
Stats
Total Posts: 104
Total Topics: 75
Most Online Today: 1
Most Online Ever: 22
(May 28, 2019, 04:37:54 am)
Users Online
Members: 0
Guests: 1
Total: 1

Author Topic: Articular cartilage repair  (Read 223 times)

0 Members and 0 Guests are viewing this topic.

fmsbi

  • Global Moderator
  • Newbie
  • *****
  • Posts: 20
Articular cartilage repair
« on: December 26, 2014, 04:00:33 am »
This review paper cited by more than 900 paper

Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects  (Review)

Hunziker, E.B. 
M.E. Müller-Institute for Biomechanics, University of Bern, Murtenstrasse 35, CH-3010, Bern, Switzerland


Abstract
Objective: To review the basic scientific status of repair in articular cartilage tissue and to assess the efficiency of current clinical therapies instigated for the treatment of structural lesions generated therein as a result of trauma or during the course of various diseases, notably osteoarthritis (OA). Current scientific trends and possible directions for the future will also be discussed. Design: A systematic and critical analysis is undertaken, beginning with a description of the spontaneous repair responses in different types of lesion. Surgical interventions aimed at inducing repair without the use of active biologics will then be considered, followed by those involving active biologics and those drawing on autogenic and allogeneic tissue transplantation principles. Cell transplantation approaches, in particular novel tissue engineering concepts, will be critically presented. These will include growth-factor-based biological treatments and gene transfection protocols. A number of technical problems associated with repair interventions, such as tissue integration, tissue retention and the role of mechanical factors, will also be analysed. Results: A critical analysis of the literature reveals the existence of many novel and very promising biologically-based approaches for the induction of articular cartilage repair, the vast majority of which are still at an experimental phase of development. But prospective, double-blinded clinical trials comparing currently practiced surgical treatments have, unfortunately, not been undertaken. Conclusion: The existence of many new and encouraging biological approaches to cartilage repair justifies the future investment of time and money in this research area, particularly given the extremely high socio-economic importance of such therapeutic strategies in the prevention and treatment of these common joint diseases and traumas. Clinical epidemiological and prospective trials are, moreover, urgently needed for an objective, scientific appraisal of current therapies and future novel approaches. © 2002 OsteoArthritis Research Society International. Published by Elsevier Science Ltd. All rights reserved.

Share on Facebook Share on Twitter


SSamani

  • Board Moderator
  • Newbie
  • *
  • Posts: 39
Re: Articular cartilage repair
« Reply #1 on: December 26, 2014, 10:40:08 am »
Hi
Download full article.
Thanks
« Last Edit: April 22, 2015, 12:16:38 am by SSamani »
The true sign of intelligence is not knowledge but imagination. Albert Einstein

 

Recent Posts ezBlock

Re: سایت انجمن by nourani
February 21, 2017, 10:10:10 am

سایت انجمن by nourani
February 21, 2017, 10:08:58 am

دومین کنگره سراسری پیشرفت‌های مهندسی باف by nourani
November 06, 2015, 10:53:12 pm

2015 TERMIS World Congress by nourani
September 03, 2015, 05:03:47 am

Dr. Zohreh Bagher The first PhD in Tissue Engineering graduated from IUMS by nourani
July 01, 2015, 04:27:43 pm

Journal of Applied Tissue Engineering was published by nourani
June 14, 2015, 09:30:06 pm

Antibacterial Hydroxyapatite (A review) by SSamani
May 02, 2015, 02:36:54 pm

Bone grafting is a big business by nourani
April 22, 2015, 09:38:11 pm

Controlled Dual Release of Functional Molecules by SSamani
April 20, 2015, 11:53:23 pm

Hyaluronic Acid Hydrogel: A Favourable Niche for Neural Stem Cells by SSamani
March 28, 2015, 01:59:53 am