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Author Topic: polyurethane for cardiac tissue engineering application  (Read 711 times)

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polyurethane for cardiac tissue engineering application
« on: December 26, 2014, 03:54:54 am »
There has been a growing trend towards applying conducting polymers for electrically excitable cells to increase electrical signal propagation within the cell-loaded substrates. A novel biodegradable electroactive polyurethane containing aniline pentamer (AP-PU) was synthesized and fully characterized by spectroscopic methods. To tune the physico-chemical properties and biocompatibility, the AP-PU was blended with polycaprolactone (PCL). The presence of electroactive moieties and the electroactivity behavior of the prepared films were confirmed by UV-visible spectroscopy and cyclic voltammetry. A conventional four probe analysis demonstrated the electrical conductivity of the films in the semiconductor range (~10(-5)S/cm). MTT assays using L929 mouse fibroblast and human umbilical vein endothelial cells (HUVECs) showed that the prepared blend (PB) displayed more cytocompatibility compared with AP-PU due to the introduction of a biocompatible PCL moiety. The in vitro cell culture also confirmed that PB was as supportive as tissue culture plate. The antioxidant activity of the AP-PU was proved using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay by employing UV-vis spectroscopy. In vitro degradation tests conducted in phosphate-buffered saline, pH7.4 and pH5.5, proved that the films were also biodegradable. The results of this study have highlighted the potential application of this bioelectroactive polyurethane as a platform substrate to study the effect of electrical signals on cell activities and to direct desirable cell function for tissue engineering applications.
Copyright 2014 Elsevier B.V. All rights reserved.

Mater Sci Eng C Mater Biol Appl. 2014 Nov 1;44:24-37. doi: 10.1016/j.msec.2014.07.061. Epub 2014 Aug 4.
Synthesis, characterization and antioxidant activity of a novel electroactive and biodegradable polyurethane for cardiac tissue engineering application.
Baheiraei N1, Yeganeh H2, Ai J3, Gharibi R4, Azami M1, Faghihi F1.
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The article was shrunk to reduce size.
« Last Edit: April 22, 2015, 12:08:30 am by SSamani »
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