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Author Topic: polyurethane for cardiac tissue engineering application  (Read 332 times)

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fmsbi

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polyurethane for cardiac tissue engineering application
« on: December 26, 2014, 03:54:54 am »
 
There has been a growing trend towards applying conducting polymers for electrically excitable cells to increase electrical signal propagation within the cell-loaded substrates. A novel biodegradable electroactive polyurethane containing aniline pentamer (AP-PU) was synthesized and fully characterized by spectroscopic methods. To tune the physico-chemical properties and biocompatibility, the AP-PU was blended with polycaprolactone (PCL). The presence of electroactive moieties and the electroactivity behavior of the prepared films were confirmed by UV-visible spectroscopy and cyclic voltammetry. A conventional four probe analysis demonstrated the electrical conductivity of the films in the semiconductor range (~10(-5)S/cm). MTT assays using L929 mouse fibroblast and human umbilical vein endothelial cells (HUVECs) showed that the prepared blend (PB) displayed more cytocompatibility compared with AP-PU due to the introduction of a biocompatible PCL moiety. The in vitro cell culture also confirmed that PB was as supportive as tissue culture plate. The antioxidant activity of the AP-PU was proved using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay by employing UV-vis spectroscopy. In vitro degradation tests conducted in phosphate-buffered saline, pH7.4 and pH5.5, proved that the films were also biodegradable. The results of this study have highlighted the potential application of this bioelectroactive polyurethane as a platform substrate to study the effect of electrical signals on cell activities and to direct desirable cell function for tissue engineering applications.
Copyright 2014 Elsevier B.V. All rights reserved.

Reference:
Mater Sci Eng C Mater Biol Appl. 2014 Nov 1;44:24-37. doi: 10.1016/j.msec.2014.07.061. Epub 2014 Aug 4.
Synthesis, characterization and antioxidant activity of a novel electroactive and biodegradable polyurethane for cardiac tissue engineering application.
Baheiraei N1, Yeganeh H2, Ai J3, Gharibi R4, Azami M1, Faghihi F1.
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SSamani

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Hi
The article was shrunk to reduce size.
Yours
« Last Edit: April 22, 2015, 12:08:30 am by SSamani »
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nourani

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